Keep an eye on Closely (1)lumefantrine will minimize the level or influence of exemestane by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. For sufferers acquiring exemestane that has a potent CYP3A4 inducer the proposed dose of exemestane is 50 mg day-to-day after a food.Prevent concomitant usage of tucatinib with CY